Adjuvant radiotherapy trials in breast cancer

Acute Skin and Pharynx Complications Following Adjuvant Hypofractionated Versus Conventional Radiotherapy in Patients with Breast Cancer

Background: Hypofractionated radiotherapy (HF) method was introduced to overcome the quickly growing tumor cells as well as shortening whole treatment course in solid tumors such as breast cancers. Here, we compared the incidence of dermatitis and pharyngitis among patients undergoing HF versus conventional fractionationated (CF) radiation therapy following surgery for breast cancer. Methods: ...

Adjuvant radiotherapy of regional lymph nodes in breast cancer - a meta-analysis of randomized trials

BACKGROUND Radiotherapy (RT) improves overall survival (OS) of breast cancer patients after breast conserving surgery and after mastectomy in patients with involved lymph nodes (LN). The contribution of RT to the regional LN to this survival benefit was poorly understood. Recently, the results of three large randomized trials addressing this question have become available. MATERIAL AND METHOD...

Adjuvant Breast Cancer Trials Collaborative Group (2007) Polychemotherapy for Early Breast Cancer: Results From the International Adjuvant Breast Cancer Chemotherapy

Right-Sizing Adjuvant and Neoadjuvant Clinical Trials in Breast Cancer.

I describe a simple and intuitive method for finding sample size for clinical trials in primary breast cancer based on neoadjuvant trial results and using the FDA's patient-level meta-analysis. Then I explain a problem with this method and how the problem can be remedied.

Risk of cardiac death after adjuvant radiotherapy for breast cancer.

BACKGROUND Women with breast cancer who are treated with adjuvant radiation have a decreased risk of local recurrence but an increased risk of mortality from ischemic heart disease. Patients with left-sided breast tumors receive a higher dose of radiation to the heart than patients with right-sided tumors. Because radiation techniques have improved over time, we investigated whether the risk of...